This paper is focused on a dual approach for silica scale control, inhibition and dissolution by use of designed chemical approaches. Inhibitors that are tested include the polyaminoamide STARBURST dendrimers (PAMAM) of generations 0.5, 1.0, 1.5, 2.0, and 2.5. Of these, only the NH2-terminated ones (PAMAM-1.0 and 2.0) show significant inhibitory activity, in contrast to COOH-terminated ones (PAMAM-0.5, 1.5, and 2.5), which show virtually no inhibition performance. The synergism between the above dendrimers and an anionic polyelectrolyte (poly(acrylamide-co-acrylate) copolymer) is also described. Addition of poly(acrylamide-co-acrylate) copolymer in silica supersaturated solutions containing PAMAM-1 or 2 alleviates the appearance of silica-PAMAM insoluble precipitates, resulting in stable colloids. The paper also describes silica dissolution approaches, as an alternative to inhibition, by using nonhazardous additives based on polycarboxylates with one to five -COOH groups (acetate, oxalate, citrate, diethylenetriaminepentaacetate, and others), mixed polycarboxylates/phosphonates (2-phosphonobutane-1, 2,4-tricarboxylate), and amino acids (L-histidine and L-phenylalanine). Their reactivity is linked to their chemical structure in this structure/function study. The presence of additional chemical groups (e.g., - PO3H2, -NH2, or -OH) in the dissolver molecule augments the dissolution process.