Catalysis Letters, Vol.104, No.1-2, 39-43, 2005
Ionic liquid promoted efficient and rapid one-pot synthesis of pyran annulated heterocyclic systems
1,1,3,3- N, N, N', N'-Tetramethylguanidinium trifluoroacetate as an ionic liquid, efficiently promotes one-pot, three-component condensation of aldehydes, alkyl nitriles and alpha-hydroxy or alpha-amino activated C-H acid to afford the corresponding pyran annulated heterocyclic systems. Ionic liquid can be recycled for subsequent reactions without any appreciable loss of efficiency.
Keywords:ionic liquid;three-component reaction;pyran annulated heterocyclic systems;4-hydroxycoumarin;4-hydroxy-6-methylpyrone;1,3-dimethylbarbituric acid;1,1,3,3-N,N,N ',N '-tetramethylguanidinium trifluoroacetate