Biotechnology Letters, Vol.27, No.20, 1605-1608, 2005
Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1 beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells
The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 mu g ml(-1))-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1 beta and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 mu g ml(-1) inhibited the LPS-induced increase in the transcription of IL-1 beta and iNOS and nitric oxide (NO) production in a dose-dependent manner.