Mixing times for inelastic shear-thinning fluids in stirred tanks have been experimentally investigated using a combination of two off-centred impellers operating in both co- and counter-rotating modes. A colour-discolouration technique based on fast acid-base reaction was used for the determination of the mixing times as well as to reveal the possible presence of caverns and dead regions. A statistical plan of experiments allowed determining the effects of the impeller position, the rotational speed, the flow behaviour index, the impeller type and their mutual interactions. A stronger influence of the impeller position on mixing times was observed for both rotating modes with fluids exhibiting pronounced shear-thinning. It was also found that segregated regions could be readily destroyed by dual off-centred impellers as compared with the single centred impeller configuration. Mixed flow impellers were shown to be less efficient in terms of mixing times than radial flow impellers. Results obtained under the best operating conditions were compared to steady stirring experiments showing the potential and drawbacks of the proposed scenarios.