Catalysis Letters, Vol.104, No.3-4, 151-156, 2005
Enantioselective hydrolytic kinetic resolution of 1,2-epoxy-3-phenoxy propane derivatives by new chiral (Salen) cobalt complexes
The enantioselective hydrolytic kinetic resolution (HKR) of racemic terminal epoxides catalyzed by new chiral (Salen) Co complex linked with Al or Ga provides a practical access of the enantiomerically enriched terminal epoxides (> 98% ee) and 1,2-diols simultaneously. In the present method, bimetallic catalysts show dramatically increased reaction rates with high enantioselectivity relative to the monomeric salen catalyst.