The volatile organic compounds(VOCs) have been recognized as major contributor to air pollution. The catalytic oxidation is one of the most important processes for VOCs destruction due to getting high efficiency at low temperature. In this study, monometallic Pt and bimetallic Pt-Ir were supported to γ-Al2O3. Xylene. toluene and MEK were used as reactants. The monometallic or bimetallic catalysts were prepared by the excess wetness impregnation method and were characterized by XRD, XPS, TEM and BET analysis. As a result, Pt-Ir bimetallic catalysts were showed higher conversion than Pt monometallic catalyst. Pt-Ir bimetallic catalyst was showed highest conversion on the TiO2 support. Pt-Ir bimetallic catalyst was showed highest conversion on the γ-Al2O3 support. In the VOCs oxidation, Pt-Ir bimetallic catalyst had multipoint active sites, so it improved the range of Pt metal state. Therefore, bimetallic catalysts were higher conversion of VOCs than monometallic ones.