Influence of chemical polymerization conditions on the yield and thermal behavior of PANI doped Dodecylbenzensulfonic (DBS) was studied by means of a 24 factorial experimental design. These conditions included temperature, concentration of dopant, concentration of oxidant and stirring rate. It was found that the thermogravimetric behavior was not sensitive to any of the conditions tested. By contrast, the yield was dependent on three of the variables studied. For 10 mmol of aniline, the maximum yield was obtained when temperature, concentration of dopant, concentration of oxidant and stirring rate were 25 degrees C, 27 mmol, 11.5 mmol and 500 rpm, respectively. The most important effects on the yield are the main effect of oxidant (APS), the interaction dopant concentration-stirring rate and the three-factor interaction effect of dopant concentration-oxidant concentration-stirring rate. The prediction equation is: Mass PANI ( g) = 1,5920 + 0,0477 DBS + 0,3496 APS + 0,1080 rpm + 0,0533 DBS* APS + 0,2504 DBS* rpm + 0,0959 APS* rpm + 0,2333 DBS* APS* rpm