Novel biodegradable, positively charged, brushlike branched polyesters, namely, poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(D,L-lactide-co-glycolide), abbreviated as (P[VAC(B0-70)-VAc0-36-VA(15-195)-VPLGA(75-240)]), were synthesized using water-soluble amine-modified poly(vinyl alcohol) backbones in a ring opening polymerization as a platform for parenteral delivery systems of hydrophilic macromolecular drug substances such as proteins and DNA. The structure of theses graft-polyesters was studied by NMR. Modifying side chain length and charge ratio, the Solubility of the polymers Could be designed to range between water-soluble and lipophilic behavior. The polymers' compact, branched architecture and their molecular mass were determined by GPC-MALLS. By differential scanning calorimetry (DSC) and wide-angle X-ray scattering (WAXS) the amorphous character of the polyesters was demonstrated. The amphiphilic nature of the polyesters allowed drug entrapment by electrostatic interactions as a function of amine modification. Amine-modified graft-polyesters were shown to possess Unusually short degradation times and merit further investigation as a platform for biodegradable delivery systems.