화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.30, No.2, 112-117, March, 2006
Export Citation
니페디핀의 삼투성 과립에서 삼투염과 반투막내의 결합제 종류가 약물방출에 미치는 영향
The Effects of Osmogant and Binder in Membrane on Nifedipine Release from Osmotic Granule
정성찬1, 조영호2, 김문석3, 이봉1, 강길선2, 3, †, 이종문2, 이해방2, 3
  • 1부경대학교 고분자공학과
  • 2전북대학교 유기신물질공학과
  • 3한국화학연구원 나노생체재료연구팀
Sung Chan Jeong1, Young Ho Cho2, 3, Moon Suk Kim4, 3, Bong Lee1, Gilson Khang2, 4, †, John M. Rhee2, 3, and Hai Bang Lee2, 4
  • 1Department of Polymer Engineering, Pukyung National University, 100, Yongdang Dong, Nam Ku, Busan 608-739, Korea
  • 2Department of Advanced Organic Materials Engineering, Chonbuk National University, 664-14, Dukjin Ku, Jeonju 561-756, Korea
  • 3, Korea
  • 4NanoBiomaterials Laboratory, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Daejeon 305-343, Korea
E-mail:
초록
약물전달 시스템 중의 하나인 삼투압정의 단점을 보완하기 위해 많은 장점을 가지는 유동층 코팅 기술을 이용하여 내부의 삼투염의 양과 반투막 내의 결합제의 종류가 다른 삼투압을 이용하는 과립을 제조하였다. 얻어진 과립은 코팅 단계에 따라 과립의 형태가 상이하였으며, 약물층에 포함된 삼투염의 양이 많을수록 많은 양의 약물을 방출하였다. 이는 과립의 내부와 외부의 삼투압 차이가 커져서 약물을 방출시키는 추진력이 증가하였기 때문으로 사료된다. 또한 반투막 의 결합제 종류에 따른 약물의 방출은 결합제의 물에 대한 용해도에 따라 달라짐을 확인할 수 있었다. 반투막 내의 다공 의 형성은 SEM과 DSC를 이용하여 확인하였으며, 물에 대한 용해도가 큰 결합제를 사용한 반투막이 더 많은 양의 약물 을 방출함을 확인하였다. 이 실험을 통해 삼투압을 이용한 과립의 약물방출은 과립 내부와 외부의 삼투압 차이와 반투막의 다공도에 의해 영향을 받는다는 것을 확인하였다.
To improve the type error of osmotic tablet which is one of the drug delivery system, osmotic granule could be manufactured by fluidized bed coating. It has drug layer containing different amount of osmogant and is coated with membrane including different types of binder. We confirmed that the morphology of osmotic granule was different at each coating step. The more amount of osmotic agent, the faster drug release was observed due to increasing the driving force for drug release from osmotic granule. And drug release from osmotic granule coated with membrane using different types of binder was differed by solubility of binders to water. The formation of pore in membrane was confirmed by SEM and DSC. Membrane using water soluble binder released more amount of drug. From these results, we assured that difference of osmotic pressure between the inside and the outside of granule and porosity of membrane have an effect on drug release from osmotic granule.
Keywords:osmotic drug delivery system;granulation;fluidized bed coating;semipermeable membrane
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