화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of the Korean Industrial and Engineering Chemistry, Vol.17, No.1, 106-110, February, 2006
Export Citation
고분자가 흡착된 약물 나노결정입자의 분무 건조
Spray Drying of Polymer-Adsorbed Drug Nanocrystal Particles
최지연, 유지연1, 김환용, 정상영, 허윤석, 홍성철, 이종휘1, †
  • 세종대학교 공과대학 나노공학과
  • 1중앙대학교 공과대학 화학신소재공학부
Ji-Yeun Choi, Ji Youn Yoo1, Hwan Yong Kim, Sang Young Jung, Yoon Suk Heo, Sung Chul Hong, and Jonghwi Lee1, †
  • Department of Nano Science and Technology, Sejong University, 98 Gunja-Dong, Gwangjin-Gu, Seoul, Korea
  • 1Department of Chemical Engineering and Materials Science, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul, Korea
E-mail:
초록
약물입자들을 나노크기로 만들어 이용하면 기존 제형에 비해 효과적일 수 있다. 특히 생체 내 낮은 흡수율을 가진 난용성 약물들은 그 입자의 크기가 감소함에 따라 흡수율과 생체이용률이 높아질 수 있다. 본 연구에서는 난용성 약물인 이트라코나졸의 나노입자를 안정화시키기 위하여 폴리비닐피롤리돈(PVP)과 다양한 당을 안정화제로 사용하였다. 당으로 안정화된 이트라코나졸 나노입자는 5일 동안의 습식분쇄 공정으로 성공적으로 제조되었다. 그 후 얻어진 액상의 입자를 분무 건조하고 그 건조분말의 재분산성을 알아보았다. 분무 건조 시 가공 변수의 효과를 알아보기 위해 온도, 압력, 유속 등을 변화시켰다. 입자크기 분석을 통해 당을 함유한 나노입자 건조분산체가 그렇지 않은 경우보다 재분산도가 더 좋은 것을 알 수 있었다. 또한 주사전자현미경(SEM)과 원자현미경(AFM)을 이용하여 나노 결정입자들이 구형에 가까운 모양인 것을 확인하였다.
If drugs are made from nanoparticles, their formulations can be more effective than the conventional ones. Especially, water insoluble drugs having low absorption rates into our body could show improvement in their adsorption and bioavailability by decreasing their particle sizes to nanometers. In this study, polyvinylpyrrolidone (PVP) and various sugars were employed as stabilizers for the nanoparticles of a water insoluble drug, Itraconazole. Nanoparticles were successfully produced by the wet slurry process for five days. Then, spray drying converted the aqueous dispersions into dry powders, and the redispersibility of dried nanoparticles into water was investigated. The effects of temperature.pressure, and flow rate were studied to understand the importance of processing variables on redispersibility. It was found in particle size analysis that nanoparticles containing sugars have better redispersibility than those without sugars. Additionally, the mainly spherical morphology of dried nanoparticles was identified by SEM (Scanning Electron Microscopy) and AFM (Atomic Force Microscopy).
Keywords:nanoparticle;stabilizer;water insoluble drug;redispersibility;ltraconazole;polyvinylpyrrolidone
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