E-science refers to the large-scale science that will increasingly be carried out through distributed globalcollaborations enabled by the Internet. The Grid is a service-oriented architecture proposed to provide access to verylarge data collections, very large scale computing resources and remote facilities. Web services, which are serverapplications, enable online access to service providers. Web portal interfaces can further hide the complexity ofaccessing facility’s services. The main use of synchrotron radiation (SR) facilities by protein crystallographers is tocollect the best possible diffraction data for reasonably well defined problems. Significant effort is therefore beingmade throughout the world to automate SR protein crystallography facilities so scientists can achieve high throu-ghput, even if they are not expert in all the techniques. By applying the above technologies, the e-HTPX project, adistributed computing infrastructure, was designed to help scientists remotely plan, initiate and monitor experimentsfor protein crystallographic structure determination. A description of both the hardware and control software is giventogether in this paper.