Click chemistry in combination with ultrafiltration has allowed the quick, efficient, and reliable multivalent con Ligation of unprotected alkyne-derived carbohydrates to three generations of azido-terininated gallic acid-triethylene glycol dendrimers Under aqueous conditions. The reported procedure allows the atom economical incorporation Of LIP to 27 Unprotected fucose, mannose, and lactose residues, in reproducible high yields (LIP to 92%), requiring only catalytic amounts of Cu. The completion of the conjugation process was clearly established in all cases by both H-1 NMR and MALDI-TOF MS.