D,L-Lactide was initiated with 1,4-butanediol in the presence of stannous octoate catalyst to provide hydroxyl -terminated poly(D,L-lactide) at 5000 and 20,000 g/mol. Portions of these materials were reacted with succinic anhydride in the presence of 1-methylimidazole to convert the hydroxyl functionality to succinic acid-terminated polymers in relatively high yield. The four materials were placed in a 7.4 pH buffered saline solution at 37 degrees C and monitored up to 180 days for their relative moisture uptake and weight loss behaviors. Carboxylic acid functionality displayed a dramatic effect on the moisture uptake behaviors for the 5000 and 20,000 g/mol polymers when compared to their respective hydroxyl functional materials. Carboxylic acid functionality significantly increased the hydrolytic degradation rate and mass loss behavior for the 5000 g/mol material, but did not affect the hydrolytic degradation rate for the higher molecular weight sample. These results suggest that moisture uptake is not the rate limiting step for the hydrolytic clegadation high molecular weiaht poly(D,L-lactide). (c) 2006 Elsevier Ltd. All rights reserved.