Adsorption of Nucleotides on β-Cyclodextrin Derivative Grafted Chitosan

Jian Bo Xiao; Xiao Qing Chen; Hong Zhu Yu; Ming Xu

Macromolecular Research, Vol.14, No.4, 443-448, August, 2006

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Adsorption of Nucleotides on β-Cyclodextrin Derivative Grafted Chitosan

Jian Bo Xiao¹, Xiao Qing Chen^{1, †}, Hong Zhu Yu¹, and Ming Xu^{2, 3}

¹College of Chemistry and Chemical Engineering, Central South University, Hunan Changsha 410083, China
²Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha 410083, China
³Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York 10021, China

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A novel β-cyclodextrin derivative (CCD-C) was synthesized with chitosan and carboxymethyl- β-cyclodextrin. Its structure was characterized by elemental analysis, infrared spectra analysis, and X-ray diffraction analysis. The adsorption properties for guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate were studied. Experimental results demonstrated that CCD-C had higher adsorption capability for guanosine 5'-monophosphate, and that the adsorption capacity for guanosine 5'-monophosphate was 74.20 mg/g. The adsorption capacity was greatly influenced by pH, time and temperature. The introduction of chitosan enhanced the adsorption ability and adsorption selectivity of β-cyclodextrin for guanosine 5'-monophosphate. This novel derivative of chitosan is expected to have wide applications in the separation, concentration and analysis of nucleotides in biological samples.

Keywords:chitosan;carboxymethyl- β-cyclodextrin;nucleotides;adsorption

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[Referenced By]

[1] Crini G, Prog. Polym. Sci, 30, 38 (2005)

[2] Shi TC, Jing YM, Sui DX, J. Chromatogr., 742, 107 (1996)

[3] Kweon DK, Song SB, Park YY, Biomaterials, 24, 1595 (2003)

[4] Khnor E, Lim L, Biomaterials, 24, 2339 (2003)

[5] Sato T, Ishii T, Okahata Y, Biomaterials, 22, 2075 (2001)

[6] Mao JS, Liu HF, Yin YJ, Yao KD, Biomaterials, 24, 1621 (2003)

[7] Gingras M, Paradis I, Berthod F, Biomaterials, 24, 1653 (2003)

[8] Wang YC, Lin MC, Wang DM, Hsieh HJ, Biomaterials, 24, 1047 (2003)

[9] Schnurch AB, Hornof M, Zoidl T, Int. J. Pharm., 260, 229 (2003)

[10] Prabaharan M, Mano JF, Drug Deliv., 12, 41 (2005)

[11] Kurita K, Prog. Polym. Sci, 26, 1921 (2001)

[12] Gupta KC, Kumar MNVR, JMS-Rev Macromol. Chem. Phys., 40, 273 (2000)

[13] Kumar MNVR, React. Funct. Polym., 46 (2000)

[14] Hitoshi S, Sei-ichi A, Prog. Polym. Sci, 29, 887 (2004)

[15] Prabaharan M, Mano JF, Carbohydr. Polym., 63, 153 (2006)

[16] Varma AJ, Deshpande SV, Kennedy JF, Carbohydr. Polym., 55, 77 (2004)

[17] Grcic JF, Voinovich D, Moneghini M, Lacan MB, Magarotto L, Jalsenjak I, Eur. J. Pharm. Sci., 9, 373 (2000)

[18] Rossi S, Ferrari F, Bonferoni MC, Caramella C, Eur. J. Pharm. Sci., 10, 251 (2000)

[19] Buschmann HJ, Knittel D, Schollmeyer E, J. Incl. Phenom. Macrocycl., 40, 169 (2001)

[20] Martin Del Valle AEM, Process Biochem., 39, 1033 (2004)

[21] Pablo RSR, Isasi JR, Gaitano GG, J. Photochem. Photobiol. A-Chem., 173, 248 (2005)

[22] Rozou S, Michaleas S, Vyza EA, J. Chromatogr. A, 1087, 86 (2005)

[23] Wang TL, Yuan LL, Li FY, J. Chromatogr. A, 1013, 19 (2003)

[24] Yang J, Lin HJ, Huang HY, Anal. Chim. Acta, 530, 213 (2005)

[25] Jursic BS, Patel PK, Tetrahedron, 61, 919 (2005)

[26] Martin Del Valle EM, Process Biochem., 39, 1033 (2004)

[27] Fakayode SO, Swamidoss IM, Busch MA, Busch KW, Talanta, 65, 838 (2005)

[28] Baglole KN, Boland PG, Wagner BD, J. Photochem. Photobiol. A-Chem., 173, 230 (2005)

[29] Fini P, Castagnolo M, Catucci L, Cosma P, Agostiano A, Thermochim. Acta, 418(1-2), 33 (2004)

[30] Auzely R, Rinaudo M, Macromol, 34, 3574 (2001)

[31] Jimenez V, Belmar J, Alderete JB, J. Incl. Phenom. Macrocycl., 47, 71 (2003)

[32] Prabaharan M, Mano JF, Macromol. Biosci., 5, 965 (2005)

[33] Venter JP, Kotze AF, Auzely-Velty R, Rinaudo M, Int. J. Pharm., 313, 36 (2006)

[34] Suvegh K, Zelko R, Macromolecules, 35(3), 795 (2002)

[35] Maestrelli F, Garcia-Fuentes M, Mura P, Alonso MJ, Eur. J. Pharm. Sci., 63, 79 (2006)

[36] Jug M, Becirevic-Lacan M, Eur. J. Pharm. Sci., 21, 251 (2004)

[37] Zhou YH, An WT, Zhang GM, Shuang SM, J. of Shanxi Univ., 28, 276 (2005)