Hydrocracking is a very important catalytic hydroconversion process by which the heavy ends of crude oil are converted into more valuable products. Kinetic modelling of such a process is particulary difficult given the complexity of the feedstocks. In this purpose, the application and the validation of a Single Events Kinetic Model for the hydrocracking of paraffins in a three phase reactor are performed. This type of model is based on a molecular approach where the whole reaction network is described. Fundamental kinetic constants were estimated from experiments carried out on hexadecane. These parameters do not depend on the chain length and were used to predict the hydrocracking of a paraffinic mixture (Fischer-Tropsch effluent) in order to validate the methodology.