Biotechnology Letters, Vol.28, No.18, 1465-1470, 2006
Improved pharmacological properties for superoxide dismutase modified with beta-cyclodextrin-carboxymethylcellulose polymer
Superoxide dismutase was glycosidated with cyclodextrin-branched carboxymethylcellulose. The modified enzyme contained 1.4 mol polymer per mol protein and retained 87% of the initial activity. The anti-inflammatory activity of superoxide dismutase was 2.2-times increased after conjugation and its plasma half-life time was prolonged from 4.8 min to 7.2 h.
Keywords:anti-inflammatory drug;carboxymethylcellulose;beta-cyclodextrin;pharmacokinetics;superoxide dismutase