Principal component analysis (PCA) is a useful tool in process fault detection, but offers little support on fault isolation. In this article, structured residual with strong isolation property is introduced. Although it is easy to get the residual by transformation matrix in static process, unfortunately, it becomes hard in dynamic process under control loop. Therefore, partial dynamic PCA(PDPCA) is proposed to obtain structured residual and enhance the isolation ability of dynamic process monitoring, and a compound statistic is introduced to resolve the problem resulting from independent variables in every variable subset. Simulations on continuous stirred tank reactor (CSTR) show the effectiveness of the proposed method.