Journal of Applied Polymer Science, Vol.102, No.5, 4573-4576, 2006
Improved pharmacokinetics and stability properties of catalase by chemical glycosidation with end-group activated dextran
Catalase was chemically modified with a monoactivated dextran derivative having a carboxylate group at its reducing end residue. The modified enzyme retained 77% of its initial specific activity and was 3-fold more resistant to tryptic degradation. The plasma half-life time was increased to 7.3-fold after glycosidation. (c) 2006 Wiley Periodicals, Inc.