화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.15, No.2, 100-108, March, 2007
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Targeted Polymeric Gene Delivery for Anti-angiogenic Tumor Therapy
Won Jong Kim, and Sung Wan Kim†
  • Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry,20 S 2030 E RM 205 BPRB, University of Utah, Salt Lake City, UT 84112-5820, USA
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Gene therapy has become a promising strategy for the treatment of genetically based diseases, such as cancer, which are currently considered incurable. A major obstacle in the field of cancer gene therapy is the development of a safe and efficient delivery system for therapeutic gene transfer. Non-viral vectors have attracted great interest, as they are simple to prepare, stable, easy to modify and relatively safe compared to viral vectors. In this review, an insight into the strategies developed for polyethylenimine (PEI)-based non-viral vectors has been provide, including improvement of the polyplex properties by incorporating hydrophilic spacer, poly(ethylene glycol) (PEG). Moreover, this review will summarize the strategies for the tumor targeting. Specifically, a targeted polymeric gene delivery system, PEI-g-PEG-RGD, will be introduced as an efficient gene delivery vector for tumor therapy, including its functional analysis both in vitro and in vivo.
Keywords:Gene therapy;polyethylenimine;poly(ethylene glycol);angiogenesis;targeted carrier
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