The dehydrogenation of propane was studied in gas-phase at 773 K over two series of silica-deposited Ir-Sn systems: the bimetallic catalysts obtained from Ir-Sn carbonyl clusters precursors and the ones prepared by deposition of a metallorganic Sn precursor onto preformed Ir nanoparticles. In the comparison, cluster-derived catalysts showed good propane conversion, optimal selectivity to propene and high stability under the severe reaction conditions.