Microfiltration membrane is increasingly used in wastewater treatment to produce a higer quality effluent. In this study a microfiltration membrane from Tunisian clay (JM(18)/SI2) was used to treat cuttlefish effluents generated from the conditioning (freezing and washing) seawater food industry which consume a great amount of water. In Sfax (Tunisia), about 1000 m(3)/day are usually discharged in the littoral. The prepared membrane is composed of two layers: a Support (SI2) with a pore diameters centred near 6.3 mu m and porosity of about 48.5%, and a microfiltration layer (JM(18)) with a mean pore size of 0.18 mu m. Cross-flow microfiltration was carried out then, in order to reduce the pollutants content expressed in term of turbidity and dissolved organic carbon (DOC). Both industrial ceramic membrane from (x-alumina and elaborated membrane from Tunisian clay were used for this study. The results reveal that the values of DOC retention rate and turbidity are nearly the same: about 65% and I NTU respectively. So, it seems that the prepared microfiltration membrane is suitable for this kind of waste water treatment.