A practical generalized predictive control strategy with novel parameter identification method from step test for multiple inputs and multiple outputs (MIMO) systems is presented in this paper. Through sequential step changes of set points, the coupled closed loop MIMO system is decoupled equivalently into four individual single open loop processes with the same input signal acting on the four transfer functions. On the basis of an identification model, the proposed controller with low computation and simple structure is very suitable for typical process control systems. Based on a HVAC plant, simulations results demonstrate the above conclusions. (c) 2006 Elsevier Ltd. All rights reserved.