The turbulence enhancement by particle wake effect is studied by large eddy simulation (LES) of turbulent gas flows passing a single particle. The predicted time-averaged and root-mean-square fluctuation velocities behind the particle are in agreement with the Reynolds-averaged Navier-Stokes modeling results and experimental results. A semi-empirical turbulence enhancement model is proposed by the present-authors based on the LES results. This model is incorporated into the second-order moment two-phase turbulence model for simulating vertical gas-particle pipe flows and horizontal gas-particle channel flows. The simulation results show that compared with the model not accounting for the particle wake effect, the present model gives simulation results for the gas turbulence modulation in much better agreement with the experimental results.