Detailed investigation on the influence of hydrodynamics, pressure, and transport properties toward a concentration polarization phenomenon in a membrane channel is crucial for membrane module design purposes. Hence, a computational fluid dynamics (CFD) simulation and modeling approach has been conducted to reveal and anticipate the membrane transport properties and concentration polarization phenomenon. The current CFD model has been validated by experimental data, which exhibited excellent accordance between simulated and experimental values. The current study has also demonstrated that physical transport properties and boundary conditions should be modeled as variables in the solution of governing equations, since these parameters potentially affect the predicted values.