This paper investigates the problem of input-to-state stability (ISS) for the general discrete-time impulsive hybrid systems. Quasi-exponential input-to-state stability criteria are established for non-linear discrete-time impulsive hybrid systems, based on the Lyapunov function. The results are then specialized to the linear discrete-time impulsive hybrid systems and fairly simple algebraic conditions are derived. Moreover, ISS small-gain properties are also investigated for a class of interconnected discrete-time impulsive systems. Several examples are given to illustrate results.