Depigmenting effect of Cinnamomum cassia Presl in B16F10 melanoma cells

Dung H. Nguyen; Duc T. M. Nguyen; Lianhua Luo; Sang-Hee Yang; Hyang-Bok Lee; Hae-Jong Kim; Jeong-Hyun Shin; Dong Man Kim; Eun-Ki Kim

Korean Journal of Chemical Engineering, Vol.24, No.5, 827-830, September, 2007

DOI10.1007/s11814-007-0048-0 Export Citation

Depigmenting effect of Cinnamomum cassia Presl in B16F10 melanoma cells

Dung H. Nguyen, Duc T. M. Nguyen, Lianhua Luo, Sang-Hee Yang, Hyang-Bok Lee, Hae-Jong Kim, Jeong-Hyun Shin¹, Dong Man Kim², and Eun-Ki Kim^†

Department of Biological Engineering, ERC of Bioseparation, Inha University, Incheon 402-751, Korea
¹Department of Dermatology, Inha University School of Medicine, Incheon 402-751, Korea
²Dept. of Biological Engineering, Yanbian University of Science and Technoloy, Yanji, China

E-mail:

To find efficient depigmenting agents, we examined several Chinese herbs for melanogenesis inhibition and toxicity. Cinnamomum cassia Presl exhibited low cytotoxicity at even high concentration (200 μg/ml). The effects on melanogenesis of cultured B16 melanoma cells, mushroom tyrosinase activity, and free radical scavenging activity were further assessed. The methanol extracts of this plant showed the suppression of melanin synthesis. Melanin content was dose-dependently decreased by this herb extract as compared with control cells. It also showed good anti-oxidative activity (IC50=3.7 μg/ml) but no inhibition of mushroom tyrosinase activity. This result showed that Cinnamomum cassia Presl extract might be useful and safe as a new whitening agent in cosmetics.

Keywords:Melanogenesis;Depigmentation;Herb;Cinnamomum cassia Presl

[References]

Hearing VJ, J. Dermatol. Sci., 37, 3 (2005)
Kim YJ, Uyama H, Cell. Mol. Life Sci., 62, 1707 (2005)
Petit L, Pierard GE, Int. J. Cosmet. Sci., 25, 169 (2003)
Bruno H, Maria GB, Francoise L, Int. J. Dermatol., 39, 801 (2000)
Cayce KA, Mc Michael AJ, Feldman SR, Dermatol Nurs., 401, 6 (2004)
Briganti S, Camera E, Picardo M, Pigment Cell Res., 16, 101 (2003)
Kim DS, Kim SY, Park SH, Choi KY, Kwon SB, Kim MK, Na JI, Youn SW, Park KC, Biol. Pharm. Bull., 28, 2216 (2005)
Solano F, Briganti S, Picardo M, Ghanem G, Pigment Cell Res., 19, 550 (2006)
Wang KH, Lin RD, Hsu FL, Huang YH, Chang HC, Huang CY, Lee MH, J. Ethnopharmacol., 106, 353 (2006)
Zhong S, Yan W, Ahn SM, Junyu Z, Ke W, Shuxia Y, Ho JH, Xuejun Z, Biol. Pharm. Bull., 29, 1947 (2006)
Barr RD, Woodger BA, Rees PH, Am. J. Clin. Pathol., 59, 36 (1973)
Findlay GH, De Beer HA, S. Afr. Med. J., 57, 187 (1980)
Phillips JI, Isaacson C, Carman H, Am. J. Dermatopathol., 8, 14 (1986)
He ZD, Qiao CF, Han QB, Cheng CL, Xu XH, Jiang RW, But PP, Shaw PC, J. Agric. Food Chem., 53, 2424 (2005)
Verspohl EJ, Bauer K, Neddermann E, Phytother. Res., 19, 203 (2005)
Tim M, J. Immunol. Methods, 65, 55 (1983)
Blois MS, Nature, 181, 1199 (1958)

[Referenced By]

[Related Articles]

[1] Hearing VJ, J. Dermatol. Sci., 37, 3 (2005)

[2] Kim YJ, Uyama H, Cell. Mol. Life Sci., 62, 1707 (2005)

[3] Petit L, Pierard GE, Int. J. Cosmet. Sci., 25, 169 (2003)

[4] Bruno H, Maria GB, Francoise L, Int. J. Dermatol., 39, 801 (2000)

[5] Cayce KA, Mc Michael AJ, Feldman SR, Dermatol Nurs., 401, 6 (2004)

[6] Briganti S, Camera E, Picardo M, Pigment Cell Res., 16, 101 (2003)

[7] Kim DS, Kim SY, Park SH, Choi KY, Kwon SB, Kim MK, Na JI, Youn SW, Park KC, Biol. Pharm. Bull., 28, 2216 (2005)

[8] Solano F, Briganti S, Picardo M, Ghanem G, Pigment Cell Res., 19, 550 (2006)

[9] Wang KH, Lin RD, Hsu FL, Huang YH, Chang HC, Huang CY, Lee MH, J. Ethnopharmacol., 106, 353 (2006)

[10] Zhong S, Yan W, Ahn SM, Junyu Z, Ke W, Shuxia Y, Ho JH, Xuejun Z, Biol. Pharm. Bull., 29, 1947 (2006)

[11] Barr RD, Woodger BA, Rees PH, Am. J. Clin. Pathol., 59, 36 (1973)

[12] Findlay GH, De Beer HA, S. Afr. Med. J., 57, 187 (1980)

[13] Phillips JI, Isaacson C, Carman H, Am. J. Dermatopathol., 8, 14 (1986)

[14] He ZD, Qiao CF, Han QB, Cheng CL, Xu XH, Jiang RW, But PP, Shaw PC, J. Agric. Food Chem., 53, 2424 (2005)

[15] Verspohl EJ, Bauer K, Neddermann E, Phytother. Res., 19, 203 (2005)

[16] Tim M, J. Immunol. Methods, 65, 55 (1983)

[17] Blois MS, Nature, 181, 1199 (1958)