In this study, hybrid catalyst containing acetate based Cu-Zn-Al precursor for direct synthesis of DME was prepared. Reactivity test of prepared hybrid catalyst was performed with varying reaction conditions. As a result of reactivity test, it was confirmed that the prepared hybrid catalyst was presented a sensitive activity according to the reaction temperature. And the pellet-typed hybrid catalyst was prepared by physical mixing method. Catalytic activity of prepared hybrid catalyst was compared with that of pellet-typed hybrid catalyst. From the result, catalytic activity of pellet typed hybrid catalyst was higher than powder typed hybrid catalyst. And the reactivity test of pellet typed hybrid catalyst was performed in the composition of coal derived gas. The conversion of hydrogen was about 83%. It was determined that the molding hybrid catalyst has an excellent catalytic activity.