Latex particles with an average diameter of 70 nm, functionalized at the surface with carboxylic groups, are chemically coated by layer-by-layer deposition onto a spherical probe attached on an atomic force microscope cantilever. The forces between poly(styrene-acrylic acid) latex nanoparticles and differently terminated zinc oxide surfaces are studied by a homemade atomic force microscope based apparatus. The results confirmed a preferred adhesion of the latex particles to zinc-terminated ZnO faces, {0001}, compared to oxygen-terminated and apolar faces. The method proposed allows the measurement of the interaction between nanometric particles and planar surfaces, which may be of interest for different applications in surface and colloid sciences.