Mesoporous alumina has been synthesized first by a traditional precipitation method in a rotating packed bed (RPB) in a scaling experiment. Aluminum nitrate was used as source of aluminum, and poly(ethylene glycol) 1540 was used as the template. The characterization showed that the ordered wormlike pores and narrow pore size distributions were obtained, and the surface area reached about 250 m(2)/g. The experimental results indicated that the structure of mesoporous alumina was related to the synthesized and assembled rate of precursor which was dominated by those factors (such as concentration of reactant, the addition rate of precipitator, and so on). Specifically, the efficiency of micromixing and dispersion which was the most important condition for the synthesis of mesoporous aluminas has been greatly intensified by the high-gravity environment in RPB. It first provided a feasible technology for volume production of mesoporous alumina.