Journal of the American Chemical Society, Vol.129, No.18, 5834-5834, 2007
Highly enantioselective insertion of carbenoids into N-H bonds catalyzed by copper complexes of chiral spiro bisoxazolines
A highly efficient copper-catalyzed asymmetric insertion of alpha-diazoesters into N-H bonds has been realized by using chiral spiro bisoxazoline ligands, affording alpha-amino acid derivatives in high yields with excellent enantioselectivities.