Well dispersed ruthenium(0) nanoparticles, stabilized in the ionic liquid agent, trihexyltetradecylphosphonium dodecylbenzenesulfonate, have been successfully prepared via a reduction reaction of the precursor [CpRuCp*RuCp*]PF6 (Cp* = C5Me5). The ruthenium(0) nanoparticles were shown to catalyze the isotope exchange reaction between B-10 enriched diborane and natural abundant B10H14 to produce highly B-10 enriched (similar to 90%) decaborane(14) products. The ruthenium(0) nanoparticles were characterized by TEM, XRD, and XPS. The B-10 enriched decaborane(14) has been analyzed by Raman spectroscopy, NMR, and high-resolution MS.