Interaction of dipyridamole with phospholipid monolayers at the air-water interface: Surface pressure and grazing incidence X-ray diffraction studies

Haas H; Caetano W; Borissevitch GP; Tabak M; Sachez MIM; Oliveira ON; Scalas E; Goldmann M

Chemical Physics Letters, Vol.335, No.5-6, 510-516, 2001

DOI10.1016/S0009-2614(00)01464-0 Export Citation

Interaction of dipyridamole with phospholipid monolayers at the air-water interface: Surface pressure and grazing incidence X-ray diffraction studies

Haas H, Caetano W, Borissevitch GP, Tabak M, Sachez MIM, Oliveira ON, Scalas E, Goldmann M

Incorporation of dipyridamole (DIP) in Langmuir monolayers of the zwitterionic phospholipid dipalmitoylphosphatidylcholine (DPPC) has been investigated using surface pressure isotherm and grazing incidence X-ray diffraction (GIXD) measurements. An expansion in the pressure-area isotherms of the DPPC monolayer was observed, which was maximum in the liquid-expanded (LE) to liquid-condensed (LC) transition region and at a DIP concentration of 2 mol%, Accordingly, the GIXD measurements indicated an expansion of the 2D lattice in the LC phase up to a surface pressure of ca, 30 mN/m, A condensation effect on the DPPC packing for high DIP concentrations, as previously suggested, can be ruled out.