we present an electrostatic mechanism that gives rise to dramatic enhancements of tunneling through the inter-nuclear Coulomb-barrier. The enhancement is due to an increase in the effective negative electric charge in the mid region between two protons (deutrons) belonging to an H-2(+) (D-2(+)) molecule placed inside a molecular cage, such as a fullerene molecule. This charge increase results in a marked reduction of the outer regions of the Coulomb-barrier, thereby dramatically increasing the nuclear tunneling rates. Coupled with compression of the molecular cage this effect may lead to meaningful enhancements in fusion rates. (c) 2006 Elsevier B.V. All rights reserved.