Selective Control of HOD photodissociation has been investigated using simple field profiles. Initial results indicate that preferential dissociation of O-H bond may be achieved from the ground vibrational state and that the O-D bond can be selectively dissociated using only the fundamental excitation in this mode. Dissociation from 2 quanta of excitation in the O-D mode produces 82.8% products with O-D bond dissociation. Preferential maximization of O-D dissociation vis-A-vis O-H bond may also be achieved from the ground vibrational state using a combination of two lasers with carrier frequencies 54920 cm(-1) and 52203 cm(-1). The use of Field Optimized Initial STate (FOIST) based scheme to enhance selective control of HOD photodissociation provides additional 6 - 8% H-O + D products compared to those obtained without FOIST. (c) 2006 Elsevier B.V. All rights reserved.