Chemistry Letters, Vol.29, No.1, 38-39, 2000
[2.2]Paracyclophane-derived N-acylosazol-2(3H)-one as a suitable planar chiral auxiliary for the enantioselective synthesis of beta-hydroxy acids
The synthesis of optically active (+)-(R)-[2.2]paracyclophano[4,5-d]-oxazol-2(3H)-one is described. The aldol reaction of N-acyl derivatives of this planar chiral auxiliary with beazaldehyde occurs with good diastereo- and enantioselectivity.