Chemistry Letters, Vol.29, No.2, 104-105, 2000
Radical cyclization reaction using a combination of phosphinic acid and a base in aqueous ethanol
Treatment of allylic ether of 2-iodophenol or 2-haloethanal allylic acetal with phosphinic acid, a base and a radical initiator (AIBN or triethylborane) in aqueous ethanol provided the corresponding radical cyclization product in excellent yield. An addition of a base is critical to employ phosphinic acid as a radical mediator.