First synthesis of subelliptenone F, an inhibitor of topoisomerase II

Ohira S; Fukamachi N; Nakagawa O; Yamada M; Nozaki H; Iinuma M

Chemistry Letters, Vol.29, No.5, 464-465, 2000

Ohira S, Fukamachi N, Nakagawa O, Yamada M, Nozaki H, Iinuma M

Subelliptenone F, a potent inhibitor of topoisomerase II, was synthesized for the first time via coupling of A and C ring components and B ring formation, Followed by Claisen rearrangement of the 3-methyl-2-butenyl ether.