Chemistry Letters, Vol.30, No.4, 370-371, 2001
A cyclic sugar unit interacts more strongly with DNA than do open-chain polyol counterparts in sugar-linked synthetic DNA intercalators
We synthesized new DNA intercalators, polyol- or cyclic sugar-linked anthraquinone derivatives. The binding affinity of these DNA intercalators is suggested to be controlled by the configuration and steric structure of sugar chain with the cyclic sugar chain interacting more strongly than the open-chain polyol unit with double stranded DNA.