Chemistry Letters, Vol.30, No.7, 634-635, 2001
Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit
A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A,)I hybridized with the complementary DNA (Tg). The hybrid showed a very sharp melting curve with T-m= 34 degreesC.