Chemie Ingenieur Technik, Vol.70, No.12, 1596-1609, 1998
Process engineering aspects of production with mycelium-forming microorganisms
This review deals with process engineering aspects of biosynthesis, morphology and rheology of mycelium-forming microorganisms, which produce secondary metabolites and proteins in semisynthetic and complex cultivation media, The interrelation of biosynthesis, morphology and rheology are discussed, Mathematical models for the biosynthesis and the morphological structures are presented. The investigations indicate that the results obtained with microorganisms cultivated in semisynthetic media cannot be directly transferred to systems with the same micro-organisms cultivated in complex media.
Keywords:NUCLEAR-MAGNETIC-RESONANCE;TOWER-LOOP REACTORS;DEACETOXYCEPHALOSPORIN-C SYNTHETASE;MORPHOLOGICALLY STRUCTUREDMODEL;PENICILLIUM-CHRYSOGENUM PELLETS;DISSOLVED-OXYGENCONCENTRATION;BIDIRECTIONAL REACTION STEPS;ISOPENICILLIN-NSYNTHETASE;SINGLE MICROBIAL PELLET;FED-BATCH CULTIVATIONS