Chemistry Letters, Vol.31, No.3, 282-283, 2002
The 5-endo-trig cyclization of gem-difluoroolefins with sp(3) carbon nucleophiles: Synthesis of 1-fluorocyclopentenes
A disfavored 5-endo-trig cyclization is accomplished in gemdifluoroolefins with sp(3) carbon nucleophiles, generated via the lithium-iodine exchange reaction of 1,1-difluoro-5-iodo-1-pentenes with tent-butyllithium, to afford 1-fluorocyclopentenes.