Chemistry Letters, Vol.32, No.8, 678-679, 2003
A one-pot synthesis of cyclic pyrido[1,2-a]quinoxaline phosphate, a new molecule of biological importance from a quinoxaline derivative of sugar
A five membered cyclic pyrido[1,2-a]quinoxaline phosphate has been first synthesized in one step in a good yield by phosphorylation of the quinoxaline derivative of sugar la with (PhO)P(O)Cl-2. Phosphorylation of the tetrols (1a and 1b) and the diol acetals with other phosphorylating agents, however, affords a dehydration product 2-(2-furyl)quinoxaline.