Chemistry Letters, Vol.32, No.10, 890-891, 2003
Pd-catalyzed cross-coupling reaction of alkyl tosylates and bromides with Grignard reagents in the presence of 1,3-butadiene
A new method for cross-coupling reaction of alkyl tosylates and bromides with Grignard reagents has been developed by the use of Pd(acac)(2) or PdCl2 as the catalyst. Addition of 1,3-butadiene is essential to afford good yields of coupling products. This reaction proceeds efficiently at room temperature using primary and secondary alkyl and aryl Grignard reagents.