Chemistry Letters, Vol.33, No.10, 1304-1305, 2004
Stereoselective preparation of alpha-hydroxycarboxamide by manganese complex catalyzed hydration of alpha,beta-unsaturated carboxamide with molecular oxygen and phenylsilane
Aerobic oxidation with the combined use of phenylsilane and a manganese complex catalyst was successfully applied to the alpha,beta-unsaturated carboxamide containing a C-2-symmetrical chiral auxiliary to afford the corresponding alpha-hydroxycarboxamide in good-to-high yield with high stereoselectivity.