Chemistry Letters, Vol.33, No.12, 1592-1593, 2004
Cross metathesis route in sphingomyelin synthesis
Cross metathesis reaction of short chain Boc sphingosine using Grubbs' 2nd generation catalyst proceeded in stereoselective manner to afford Boc sphingosine in good yield. An efficient synthesis of sphingomyelin was achieved from the obtained Boc sphingosine using our own phosphorylation reagent.