This letter demonstrates the high chiral discrimination of 2,2'-ditellurobis(2-deoxy- beta-cyclodextrin) (2-TeCD, 1) in recognizing dansyl-(L)-phenylalanine (DLP) and danSyl-(D)-phenylalanine (DDP). 1 is shown to be a very useful host in fluorescent sensing. It exhibits very good chiral enantioselectivity with a ratio of K-L/K-D = 3.71 in a stoichiometry of 1:1 in the chiral discrimination of DPs.