Chemistry Letters, Vol.35, No.6, 660-661, 2006
Pyrene-modified DNA aptamer as a fluorescent biosensor with high affinity and specificity for ATP sensing
The fluorescence properties of anti-ATP apatmers labeled with a pyrenylmethyl group at the 2-positin were investigated. The labeling of the nucleoside residue at the stem region adjacent to the ligand-binding pocket gave a fluorescent biosensor having high affinity yet retaining its specificity for ATP.