The palladium/copper (Pd/Cu)-catalyzed cross-coupling of bromobenzene and 2-methylbut-3-yn-2-ol has been investigated to ascertain the factors influencing the reaction rate. Most usefully; the reaction is carried out using Pd(acetate), as catalyst precursor in combination with PPh3 and a copper salt. A primary or: a cyclic amine is best suited as the reaction solvent. Under these conditions, substrate to palladium ratios of 2000 can be used.