The support-effect was investigated in the enantioselective hydrogenation of isophorone over Pd catalysts prepared on different carbon supports. Carbon supports with different specific surface area and activated carbons with different surface chemistry were used. The Pd catalysts, obtained by different reduction methods of the catalyst precursor, had different dispersion. The low dispersion was advantageous for the high enantioselectivity and the different supports had influence on the ee due to their different specific surface area and surface chemistry.