Supported nickel catalysts were prepared from nickel acetylacetonate, and then modified in a solution containing tartaric acid and sodium bromide. The enantio-differentiating hydrogenation of methyl acetoacetate was carried out over this catalyst. The effects of the preparation variables of the supported nickel catalysts on the optical yield and the effects of the conditions for the nickel surface modification on the optical yield were examined. The catalysts were also characterized by XRD and TEM. The maximal optical yield of 87% was attained when crystallized alpha-alumina (sumico rundum) was used as a support.